Keeping in mind that I've only watched the Star Wars movies once, and never watched Trek, I've gotta go with the Enterprise on this one.

As a ship, you'd have to think that the Destroyer would have it trumped; those things are huge and nasty. But it's all about the people inside. You have the cast of friggin' Star Trek in the Enterprise vs. a typically inept villain who we may never actually see. There are lots of Destroyers out there, we can basically just assume that this thing isn't a dreadnought (lol I did homeworkz), so it's not got the top guys in it. Just some lousy Empire extra.

After a quick scan of the Intrawebs, I've concluded that throughout Star Trek, only two Enterprises have been destroyed. Anyone have a count of how many Destroyers have been downed?