Hrm... I think Yu Yu Hakusho takes the place for my favorite anime. It's got romance, action, humor.. a good combination of each to make it an enjoyable anime to watch.

Kare Kano (His and Her Circumstances) is up there too. I love romance anime's, and I think the english VA's did a wonderful job.. even though a lot of them are recognizable from pokemon. Arima's VA is my absolute favorite though.