This could be interesting...

Super Mario (Super Mario Bros. Super Show) - Friend, brother, hero... No cartoon battle would be complete without everyone's favorite plumber!
Homer Simpson (The Simpsons) - The avatar of the American man.
Edward Elric (Full Metal Alchemist) - Determined, devoted, and he goes nuts when someone calls him short...
Inuyasha (Inuyasha) - Rude, loud, feeble-minded... He's like the Homer Simpson of anime.
Slade (Teen Titans) - Calm, collected, obsessed with machines, seemingly unstoppable... A truly 'great' villian.
Fred Flintstone (The Flintstones) - The Homer Simpson of cavemen... Wait, did I just repeat myself? o_O
Superman (Justice League) - Considered by at least one source as the most famous pop culture icon of all time... That's reason enough.